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Is Bread the Villain?
What if bread and gluten aren't the real problem?

I was told I had a gluten allergy (insert sad music)
In that moment, I saw my life flash before my eyes. No more pizza? No more sandwiches? No more bread? Was life even worth living? đ
Bread was a key ingredient in all my favorite foodsâŠuntil I was told it wasnât helping but instead hurting me. It was all because of a parasite but it was still something I have had to deal with for nearly 16 years.
Recently in some of my allergy testing, I was told the allergy no longer showed up. That is a different story and one Iâm preparing to test out soon.
I remember reading how Mark Cuban encouraged the Dallas Mavericks during their championship season to not eat gluten.
For many, not eating gluten is a fad, a trend, a diet, a âhealthyâ choice or a necessity.
Is bread really the enemy? Is gluten the enemy? Why does it seem allergies are on the rise across the board? What if there is something else going on but gluten and bread have been pegged as the bad guy?
Even the latest food pyramid seems to show carbs and grains as not as healthy as was once thought.
They went from being the hero (old food pyramid) to being the villain (new food pyramid).
But what if thereâs more to the story? My friend James did a deep dive and he shares his thoughts below:

My friend James wrote the below article and I asked him if I could share it here. Itâs lengthy, itâs in depth, but itâs got me chewing on all the possibilities that he touches on. Iâd love to hear your thoughts.
Iâd do almost anything to have a real pizza again đ
What If Itâs Not the Gluten?
An Investigation Into Why Millions May Be Avoiding Bread for the Wrong Reasons
By James Gurtner Jr
In the summer of 2005, the summer before I started high school, I spent my days cutting dough and bagging bread at my familyâs bakery in Kennesaw, Georgia. Staff of Life Foods was a full commercial operationâwe were baking over 400 loaves per day of whole grain bread made the way my grandfather had made it in Brazil, and the way my father had learned from him: freshly ground flour, simple ingredients, no additives.
The bread was light and airyâproof that whole grain bread didnât have to be the dense brick people expected. But because we were doing everything the healthiest way possible, our loaves would only last about three days on the shelf unless frozen. We approached Whole Foods, thinking theyâd be the perfect partner for what we were making. They turned us down. Our bread would compete with their own bakery products.
We didnât know it then, but we were swimming against a cultural tsunami. Within six years, William Davis would publish Wheat Belly, calling wheat a âperfect, chronic poisonâ and âthe single largest contributor to the nationwide obesity epidemic.â The book sold over 2 million copies. Two years later, David Perlmutterâs Grain Brain would claim carbohydrates are âdestroying your brain.â That sold another 1.5 million. The gluten-free market exploded from under $1 billion in 2006 to nearly $12 billion by 2015âa 1,100% increase in less than a decade.
The world wasnât just ânot readyâ for our bread. It was being actively taught to fear it.
We ran out of money and sold the bakery to Sue Becker of Bread Beckersâwhose work youâll read about later in this article. Twenty years later, the science has finally caught up to what my grandfather knew instinctively: the problem isnât bread. The problem is what industrial processing has done to itâand what bestselling books have done to our relationship with it.
The conventional wisdom that 6-10% of Americans are âgluten sensitiveâ may be dramatically wrong. When self-reported gluten-sensitive individuals undergo double-blind, placebo-controlled testing, only 16% actually react to glutenâwhile 40% respond equally to placebo (Molina-Infante et al., Nutrients, 2015). The real culprits may be hiding in plain sight: industrial processing methods, chemical additives, pesticide residues, and the elimination of traditional fermentation that once made wheat digestible for millennia.
This investigation examines mounting scientific evidence suggesting that what millions experience as âgluten sensitivityâ may actually be a reaction to how modern flour is processed, not to gluten itself. For the estimated 30-40 million Americans avoiding wheat, this distinction could be life-changingâthe difference between permanent dietary restriction and potentially healing their relationship with bread.
The Bestsellers That Taught America to Fear Bread
Before examining the science, itâs worth understanding how we got here. The anti-grain movement didnât emerge from peer-reviewed research. It emerged from bookstores.
William Davis, a Milwaukee cardiologist, published Wheat Belly on August 30, 2011. His central argument: modern wheat is a âFrankenwheatââa âmutant product of genetic tinkeringâ fundamentally different from wheat consumed before 1960. He claimed wheat is âas addictive as many drugsâ due to opioid-like compounds called exorphins. The book became a #1 New York Times bestseller. Kelloggâsâthe worldâs largest cereal makerâexperienced its biggest sales drop since the 1970s.
Neurologist David Perlmutter followed in September 2013 with Grain Brain, claiming carbohydrates are âdestroying your brainâ and linking even âhealthyâ whole grains to dementia, ADHD, anxiety, and depression. It hit #1 on the New York Times, Wall Street Journal, and USA Today bestseller lists simultaneously.
The Paleo diet provided the evolutionary framework: humans supposedly havenât adapted to grains because agriculture began only 10,000 years ago. Google named Paleo the #1 most-searched diet in both 2013 and 2014, with an estimated 3 million Americans following its grain-free principles.
The cultural impact was measurable. Bread sales fell 11.3% between 2008 and 2013. Gallup tracking showed Americans actively trying to avoid carbohydrates rose from 20% to 27%. By 2015, 82% of people eating gluten-free had NOT been diagnosed with celiac diseaseâmost believed these foods were simply âhealthierâ (Mintel, 2015).
But hereâs what the bestseller lists didnât tell you: the scientific community systematically refuted these claims. A 2013 peer-reviewed study in the Journal of Cereal Science concluded: âStatements made in the book of Davis, as well as in related interviews, cannot be substantiated based on published scientific studies.â Wheat geneticist Dr. Ravi Chabbar at the University of Saskatchewan studied 37 wheat varieties grown since the 1800s and found wheat is âdifferent because we can grow more of it... but itâs not different in terms of the nutrition that it delivers.â
Nicola McKeown at Tufts Universityâs Friedman School found those consuming at least three servings of whole grains daily had 10% lower belly fat than those eating noneâthe opposite of Davisâs âwheat bellyâ claim.
The books won the cultural battle. The science told a different story.
The 2026 Dietary Guidelines: When Policy Follows Ideology
As if the confusion around grains werenât already damaging enough, the federal government just made things worse. In January 2026, the USDA released new Dietary Guidelines that dramatically demote grains from the foundation of the food pyramid to its narrow tipâcutting recommended servings nearly in half while eliminating any guidance on refined grains whatsoever.
The previous 2020-2025 guidelines recommended 6 ounce-equivalents of total grains daily for a 2,000-calorie diet, with at least half from whole grains. The new guidelines recommend just 2-4 servings of whole grains daily, with no serving recommendation for refined grains. Instead, refined grains are characterized as âhighly processed, refined carbohydratesâ that should be âsignificantly reduced.â
This might seem like vindication for the anti-grain movement. But hereâs whatâs alarming: the administration rejected 30 of 56 recommendations from its own scientific advisory committee to reach these conclusions (Center for Science in the Public Interest, 2026). A STAT News investigation found that eight of nine authors of the new âScientific Foundationâ document had financial ties to the beef and dairy industries.
Dr. Deirdre Tobias, a Harvard nutrition professor who served on the 2025 Dietary Guidelines Advisory Committee, stated: âThe reviews themselves, as well as their overall presentation and integration, deviate significantly from the rigorous process that the HHS developed for the DGAs to ensure the evidence base and its committeesâ conclusions were replicable, unbiased, transparent, and free from non-scientific influences.â
The problem isnât distinguishing between processed and whole grainsâthat distinction matters enormously, as this article will demonstrate. The problem is that the new guidelines throw the baby out with the bathwater, reducing recommendations for whole grains that decades of research show reduce mortality, heart disease, cancer, and diabetes. The Physicians Committee for Responsible Medicine has filed a formal petition to withdraw the guidelines over documented industry influence.
The irony is profound: as federal policy moves to discourage grain consumption based on industry pressure, the scientific evidence for properly prepared whole grains has never been stronger. What we need isnât less grainâitâs better grain, prepared the way humans ate it for thousands of years before industrial processing changed everything.
A Prophet of Bran Bread Warned Us 188 Years Ago
On the streets of Boston in 1837, a mob of butchers and commercial bakers marched on the hotel where Presbyterian minister Sylvester Graham was lecturing about bread. The âGrahamitesâ inside reportedly dispersed the angry men by dropping bags of lime from the roof. Grahamâs crime? Publishing a treatise arguing that refined white flour was making Americans sick.
âIt is, probably, speaking within bounds, to say that nine tenths of the adults in civic life are more or less afflicted with obstructions and disturbances in the stomach and bowels,â Graham wrote in his Treatise on Bread and Bread-Making (1837). âAnd I cannot but feel confident that the use of superfine flour bread is among the important causes.â
Graham documented that bakers were adulterating bread with âalum, sulphate of zinc, sub-carbonate of magnesia, sulphate of copperââeven âchalk, pipe clay and plaster of Paris.â Ralph Waldo Emerson mockingly called him âthe prophet of bran bread.â The baking industry called him a nuisance.
Nearly two centuries later, Grahamâs concerns appear prophetic. The U.S. still permits flour additivesâincluding potassium bromate, azodicarbonamide, and chlorine bleachingâthat are banned throughout Europe, Canada, and much of the developed world.
The 1870s Transformation That Changed Everything
The timeline of modern digestive complaints aligns remarkably with industrial flour processing. In 1878, the Washburn âAâ Mill in Minneapolis installed the first commercially significant roller mill in Americaâa technology that could âgrind enough flour to make 12 million loaves of bread in a day.â By the early 1900s, stone mills had virtually disappeared from commercial production.
What changed wasnât just scale. Roller milling enabled efficient separation of three components that stone mills had always kept together: the bran (14% of kernel, containing fiber, B vitamins, minerals), the germ (2.5% of kernel, containing vitamin E, oils, antioxidants), and the endosperm (83% of kernel, primarily starch and protein).
A 2024 UC San Francisco study tracking nutrients from raw wheat through milling to finished bread found refined flour lost up to 72% of major minerals and 64% of trace minerals compared to whole wheat (Mayer et al., Journal of the American Society for Nutrition). This isnât enrichment mathâitâs basic subtraction.
The consequences appeared within decades. âWith the advent of industrialized roller milling and mass refining of grains in about 1880, worldwide epidemics of pellagra and beriberi began,â noted the American Journal of Clinical Nutrition (Mozaffarian et al., 2011). These deficiency diseases arose because B vitamins had been stripped from the popular white flour. By 1940, the situation was severe enough that the U.S. government mandated âenrichmentââadding synthetic vitamins back to flour to replace what processing had removed.
Sue Beckerâs 30-Year Experiment in Fresh-Ground Flour
In 1991, Sue Becker came across a publication about the history of white flour and American health decline. She bought a grain mill that week and started making bread for her familyâthen consisting of six children. What happened next changed her life.
âAlmost immediately, and without any other dietary changes, little health complaints that she and her children had learned to live with started clearing up,â her company Bread Beckers reports. âFatigue, constipation, sugar cravings, chronic congestion, even warts: all gone in a few weeks.â
By 1992, Becker had founded Bread Beckers in Woodstock, Georgia, with a radical message: âI do not think I am supposed to make bread for the world. I think I am supposed to teach the world to make bread for themselves.â It was Sue who eventually purchased our equipment when my familyâs bakery ran out of capitalâa passing of the torch that kept the mission alive even as our commercial venture ended.
Over 30 years, Beckerâwho holds a Food Science degree from the University of Georgiaâhas collected thousands of testimonials. Her companyâs website documents cases of IBS resolution, eczema clearing, migraines stopping, and cholesterol improving. Most striking: âMany people with known wheat/gluten sensitivities (not genetic celiac) have shared with us that real bread made only from freshly milled whole grains... is easily digested with no adverse reactions.â
Beckerâs central claim involves oxidation: âOnce milled, as much as 45% of nutrients are oxidized in the first day alone. In 3 days, just 72 hours later, 90% of nutrients are lost, all to oxidation alone.â This is exactly what we experienced at Staff of Life Foodsâour bread only lasted three days precisely because we werenât using the preservatives and stabilizers that give commercial bread its unnatural shelf life.
Scientific literature confirms rapid oxidation of wheat germ oils. A Journal of Agricultural and Food Chemistry study (Srivastava et al., 2007) found significant rancid odor and flavor in untreated wheat germ after three weeks. A PLOS One study (Xu et al., 2021) showed wheat germ stability limited to âa few daysâ without stabilization treatment. The principleâthat freshly ground flour differs biochemically from aged commercial flourâhas scientific grounding.
The Landmark Study That Turned Gluten Sensitivity on Its Head
In 2018, a research team from Oslo and Monash University published findings in Gastroenterology that should have made international headlines. They took 59 people with self-reported non-celiac gluten sensitivity and gave them three different challenges: gluten (5.7g), fructans (2.1g), or placeboâeach for seven days in a double-blind crossover design (Skodje et al., 2018).
The results contradicted everything the participants believed about their own bodies.
Fructans caused significantly more symptoms than gluten. Overall gastrointestinal scores: Fructan 38.6, Gluten 33.1, Placebo 34.3. Among individual participants, 24 had their worst symptoms on fructan, 22 on placebo, and only 13 on gluten.
âFructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity,â the researchers concluded.
Fructans are FODMAPsâfermentable carbohydrates that occur naturally in wheat. Theyâre poorly absorbed in the small intestine and fermented by gut bacteria, causing gas, bloating, and distress. Crucially, fructans are dramatically reduced by sourdough fermentationâup to 90% reduction with proper proofingâwhile gluten is not meaningfully reduced by standard bread-making.
A 2015 meta-analysis of 10 double-blind, placebo-controlled trials (1,312 patients) found that only 38 of 231 NCGS patientsâjust 16%âshowed gluten-specific symptoms. Meanwhile, 40% demonstrated a nocebo response, reacting equally to placebo (Molina-Infante et al., Nutrients).
What Modern Flour Actually Contains
The additives in todayâs commercial flour would make Sylvester Grahamâs head spin. While Graham warned about alum and chalk, modern flour can contain:
Bleaching agents: Chlorine gas, chlorine dioxide, and benzoyl peroxide whiten flour and modify its baking properties. A 2017 ScienceDirect study first reported that chlorine bleaching creates alloxanâa compound used in laboratories to induce diabetes in mice by destroying pancreatic beta cells (Wang et al., Food Chemistry). These bleaching agents are banned in the EU but permitted in the United States.
Potassium bromate: This dough conditioner, used commercially since 1923, is classified by the International Agency for Research on Cancer as âpossibly carcinogenic to humans.â Japanese research found it induced kidney tumors, thyroid tumors, and mesotheliomas in rats (Kurokawa et al., Cancer Research, 1990). Itâs banned in the EU (1990), Canada (1994), China (2005), and India (2016)âbut remains legal throughout most of the United States except California, which banned it in 2023.
Azodicarbonamide (ADA): This whitening agentâalso used in yoga mats and foam insulationâbreaks down during baking into semicarbazide (linked to cancers in mice) and urethane (classified as âreasonably anticipated carcinogenâ by the U.S. Department of Health and Human Services). The World Health Organization linked workplace exposure to ârespiratory issues, allergies and asthma.â After a 2014 controversy dubbed âyoga mat bread,â major chains including Subway, Wendyâs, and McDonaldâs voluntarily removed ADA.
Glyphosate residues: Perhaps most concerning for gut health, pre-harvest application of glyphosate (the herbicide in Roundup) to wheatâa practice called âdesiccationâ that began in Scotland in the 1980sâhas become widespread. In Canada, 90-95% of wheat acres in Manitoba are sprayed pre-harvest with glyphosate.
Canadian Food Inspection Agency testing (2015-2017) found glyphosate in 95% of wheat bran samples, 91% of crackers, 87% of cream of wheat, 82% of cookies, 79% of pasta, and 77% of flour. A 2020 critical review noted that glyphosate inhibits the shikimate pathway found in bacteriaâand that pathogenic bacteria are more resistant to glyphosate than beneficial gut bacteria. âGlyphosate residues on food could cause dysbiosis since pathogenic/bad bacteria are more resistant to glyphosate compared to commensal/good gut bacteriaâ (Motta et al., PNAS).
The Sardinian Centenarians Who Never Stopped Eating Bread
While Americans debate whether bread is poison, women in Sardiniaâs mountainous Blue Zone have been making fresh bread and pasta daily for generationsâand living to extraordinary ages. The island boasts the worldâs highest concentration of male centenarians, and their diet tells a story that contradicts everything the anti-grain movement claims.
Whole grains comprise 47% of the traditional Sardinian diet, compared to just 6.5% of the American diet (Pes et al., European Journal of Clinical Nutrition, 2013). Dan Buettner, the National Geographic explorer who identified the worldâs Blue Zones, documented the Melis family of Perdasdefoguânine siblings with a collective age of 861 years, the longest-lived family in recorded history. The oldest reached 109.
âEvery day of their life, they had the exact same lunch,â Buettner reported. âA sourdough bread, a three-bean minestrone... and then they had a small glass, Iâm talking two or three ounce glass, of wine.â
The bread of Sardinia is pane carasau, also called âcarta di musicaâ (sheet music bread) because traditional sheets were thin enough to read music through before baking. Archaeological evidence dates this bread to before 1000 BCEâremains were found in excavations of Nuraghi, the ancient stone towers dotting the island.
Traditional pane carasau requires durum wheat semolina, water, salt, and a sourdough starter called âframmentuâ or âmadrighe.â Research published in the Journal of Ethnic Foods found that lactic acid bacteria in Sardinian sourdough starters produce âspecial sets of peptides and Îł-aminobutyric acid with antihypertensive effectsâ (Mancini et al., 2021). Buettner noted that âin Sardinia, a sourdough bread, leavened with lactobacillus, actually lowers insulin response to a meal.â
These arenât people who avoided bread to achieve longevity. They built their longevity around it.
When Avoiding Bread Becomes the Disease
For the estimated 72% of Americans on gluten-free diets who have neither celiac disease nor diagnosed gluten sensitivity, the decision to eliminate grains may be causing more harm than the bread they fear.
The nutritional price runs deep. Systematic reviews have documented that gluten-free dieters commonly develop deficiencies in fiber, iron, zinc, magnesium, folate, B vitamins, calcium, and vitamin D (Vici et al., Clinical Nutrition, 2016). Iron deficiency persists in 14-41% of adults on gluten-free diets even when theyâre carefully following the protocol.
The gut microbiome damage may be even more consequential. Research published in Genome Medicine tracking 21 healthy volunteers on a four-week gluten-free diet found decreased populations of beneficial butyrate-producing bacteria and four species of Bifidobacterium (De Palma et al., 2009). These bacteria arenât optional passengersâthey produce short-chain fatty acids that suppress colonic inflammation, protect DNA from damage, maintain intestinal barrier integrity, and may even lower colorectal cancer risk.
The Harvard Study That Should Have Changed Everything
A landmark study published in the British Medical Journal in 2017 by researchers at Columbia University and Harvard Medical School should have ended the debate about gluten-free diets for healthy people. It didnât.
The study, led by Dr. Benjamin Lebwohl of Columbiaâs Celiac Disease Center, followed 110,017 participantsâ 64,714 women in the Nursesâ Health Study and 45,303 men in the Health Professionals Follow-up Studyâfor 26 years, encompassing 2,273,931 person-years of data. During that time, 6,529 participants developed coronary heart disease.
The findings were unequivocal: participants in the lowest fifth of gluten intake had a coronary heart disease incidence rate of 352 per 100,000 person-years, while those in the highest fifth had a rate of only 277 per 100,000 person-years. Those eating the most gluten had lower heart disease rates.
âLong term dietary intake of gluten was not associated with risk of coronary heart disease,â the researchers concluded. âHowever, the avoidance of gluten may result in reduced consumption of beneficial whole grains, which may affect cardiovascular risk. The promotion of gluten-free diets among people without celiac disease should not be encouraged.â
Citation: Lebwohl B, Cao Y, Zong G, et al. âLong term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study.â BMJ. 2017;357:j1892. doi:10.1136/bmj.j1892
Whole Grains Donât Just Avoid HarmâThey Actively Protect
The evidence for whole grain benefits doesnât rest on a handful of studies. A BMJ meta-analysis incorporating 45 studies found that consuming 90 grams of whole grains daily (about three servings) reduced all-cause mortality by 17%, cardiovascular mortality by 22%, cancer mortality by 15%, and diabetes mortality by a striking 48% (Aune et al., BMJ, 2016). The dose-response relationship was nearly linear, with benefits continuing up to seven servings daily.
For type 2 diabetes prevention specifically, the numbers are remarkable. Three Harvard cohort studies tracking 194,784 participants documented 18,629 diabetes cases over 4.6 million person-years. Those with the highest whole grain consumption had 29% lower diabetes risk (Hu et al., PLOS Medicine, 2020). Meanwhile, the American Heart Association found that people with lower gluten intake were actually 13% more likely to develop type 2 diabetes over a 30-year periodâthe opposite of what grain-free advocates claim.
Blue Zone populationsâthe worldâs longest-lived communitiesâoffer living proof of these findings. From Sardiniaâs whole-grain sourdough bread to Ikariaâs barley and Nicoyaâs corn tortillas, whole grains form dietary staples in all five regions. These populations donât fear bread; theyâve built their longevity around it.
What Ideal Wheat Processing Looks Like Today
If the problem isnât wheat itself but what weâve done to it, the solution becomes clear: return to traditional methods. Hereâs what the science and centuries of practice suggest:
Step 1: Start with organic ancient wheat varieties.
A landmark 2018 study from the Leibniz Institute analyzing 40 wheat varieties found that einkorn showed no detectable alpha-amylase/trypsin inhibitors (ATIs) in five of eight samples testedâthe inflammatory proteins now linked to non-celiac wheat sensitivity (Zevallos et al., Gastroenterology). By contrast, speltâoften marketed as a gentler alternativeâcontained more ATIs than modern common wheat.
The reason lies in einkornâs unique genetics. As a diploid grain with only 14 chromosomes (versus modern wheatâs 42), einkorn lacks the D genome that contains the highly immunotoxic 33-mer gliadin peptide. While einkorn actually contains more total gluten protein (15-18%) than modern wheat (10-12%), that gluten has a fundamentally different structureâone that appears far easier for the human digestive system to handle.
Best ancient wheat varieties for sensitive digestion (ranked by research): Einkorn (lowest ATIs, best tolerance evidence), Kamut/Khorasan (clinical trials showed IBS symptom reduction), Emmer (only one celiac epitope detected), and Spelt (use with cautionâhigh ATI content). Sources include Grand Teton Ancient Grains, Bluebird Grain Farms, and Barton Springs Mill.
Step 2: Grind with a home stone mill.
Fresh-milled flour contains the entire wheat berryâbran, germ, and endospermâalong with oils that begin oxidizing within 72 hours of milling. Commercial flour, milled months before reaching store shelves, has lost most of these volatile nutrients.
The Mockmill 200 ($349-399) leads the market with German-engineered corundum-ceramic stones that grind cool enough to preserve nutrients (flour temperature around 108°F), producing 200 grams of fine flour per minute with a 12-year warranty. For premium aesthetics, the Mockmill Lino 200 ($739) wraps the same performance in wood and natural acrylic stone housing.
The KoMo Fidibus Classic ($499-579), hand-built in Austria, operates more quietly (88 decibels versus Mockmillâs 96) with solid beechwood housing. For budget-conscious bakers, the Mockmill KitchenAid Attachment ($242) brings stone milling to existing stand mixers.
Step 3: Ferment with a sourdough starterâbut get the timing and temperature right.
This is where the science gets precise. The optimal fermentation âsweet spotâ is 12-24 hours at 75-82°F (24-28°C) with a final dough pH of 4.0-4.5.
The two primary organic acids in sourdoughâlactic and aceticâcreate fundamentally different effects. Lactic acid produces a mild, yogurt-like sourness; acetic acid delivers the sharp, vinegar-like tang. The ideal ratio between these acids falls between 3:1 and 5:1 (lactic to acetic), with ratios of 80% lactic to 20% acetic producing optimal flavor and digestibility (GĂ€nzle et al., Applied and Environmental Microbiology, 2009).
Temperature is the master control. At warmer temperatures (86-99°F), bacteria produce more lactic acid and ethanol, creating milder bread. At cooler temperatures (60-72°F), the same bacteria shift toward producing more acetic acid, creating tangier bread. The sweet spot of 75-82°F balances both acids while allowing yeast and bacteria to work in productive harmony.
Fermentation timing guide for FODMAP reduction: 6-8 hours yields 50-60% fructan reduction (moderate benefit). 12 hours yields 69-75% reduction (minimum effective threshold). 16-24 hours yields 70-90% reduction (optimal range). Beyond 24 hours, you get diminishing returnsâand risk over-fermentation (Struyf et al., Journal of Cereal Science, 2017).
What about harmful fermentation byproducts? The concerns are mostly overblown. Biogenic amines (including histamine) remain remarkably low in properly fermented sourdoughâtypically below 10 mg/kg, far below the 2,500 mg/kg found in aged cheese. Alcohol evaporates during baking, leaving less than 2% in finished bread.
The one legitimate concern for IBS sufferers: mannitol production. This sugar alcohol (classified as a FODMAP) can increase by up to 550% during fermentation. The tradeoff is real: the same bacteria that reduce fructans also produce mannitol. For most people this isnât an issue, but those with severe IBS may benefit from sourdoughs made with specific homofermentative bacterial strains (like L. plantarum) that donât produce mannitol.
Step 4: Bake and enjoyâwithin the first few days.
Use your freshly milled flour within 2-3 days for maximum nutritional benefit. Bake your sourdough after the full fermentation period to an internal temperature of 200-205°F, and consume within a few days of baking. Store any extra flour in the freezer to slow oxidation.
This approach addresses multiple mechanisms simultaneously: ancient wheatâs near-absence of inflammatory ATIs, fresh-millingâs preservation of nutrients, and long fermentationâs dramatic reduction of fructans and phytic acid. Itâs the same basic approach Sardinian women have practiced for millenniaâand what my grandfather knew in Brazil, what my father knew in Georgia, and what we tried to share with the world at Staff of Life Foods before the market was ready to listen.
Iâve got some homework to do and yes on my list is trying to make some fresh Einkorn bread made like they did in the ancient world. Stay tunedâŠ
-Jared
(References down below)
P.S. - My wife has a beautiful newsletter where she shares her perspectives on tending the land, recipes, womenâs health and more.
Iâd love to hear goals for 2026. đ
I write this newsletter each week because I feel my best when my body, mind and soul are all healthy. I want the same for you. If you feel like youâve seen something valuable here, please do me a favor and forward this newsletter to a friend or let me know what you think by replying to this email or texting me - (310) 879-8441

P.S. - This newsletter does not provide medical advice. The content, such as graphics, images, text, and all other materials, is provided for reference and educational purposes only. The content is not meant to be complete or exhaustive or to be applicable to any specific individual's medical condition.
Selected References
Aune D, Keum N, Giovannucci E, et al. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies. BMJ. 2016;353:i2716.
De Palma G, Nadal I, Collado MC, Sanz Y. Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects. Br J Nutr. 2009;102(8):1154-1160.
GĂ€nzle MG, Loponen J, Gobbetti M. Proteolysis in sourdough fermentations: mechanisms and potential for improved bread quality. Trends Food Sci Technol. 2008;19(10):513-521.
Lebwohl B, Cao Y, Zong G, et al. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. BMJ. 2017;357:j1892.
Molina-Infante J, Santolaria S, Sanders DS, Fernåndez-Bañares F. Systematic review: noncoeliac gluten sensitivity. Aliment Pharmacol Ther. 2015;41(9):807-820.
Pes GM, Tolu F, Dore MP, et al. Male longevity in Sardinia, a review of historical sources supporting a causal link with dietary factors. Eur J Clin Nutr. 2015;69(4):411-418.
Skodje GI, Sarna VK, Minelle IH, et al. Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity. Gastroenterology. 2018;154(3):529-539.
Struyf N, Van der Maelen E, Hemdane S, et al. Bread dough and bakerâs yeast: An uplifting synergy. Compr Rev Food Sci Food Saf. 2017;16(5):850-867.
Vici G, Belli L, Biondi M, Polzonetti V. Gluten free diet and nutrient deficiencies: A review. Clin Nutr. 2016;35(6):1236-1241.
Zevallos VF, Raker V, Tenber S, et al. Nutritional wheat amylase-trypsin inhibitors promote intestinal inflammation via activation of myeloid cells. Gastroenterology. 2017;152(5):1100-1113.
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